Traditionally, lectures about transfusion reactions have largely focused on the usual suspects typically invoked in their causation, e.g., febrile non-hemolytic reactions, allergic reactions, pulmonary reactions, hemolytic reactions, etc. This session will focus on the “Un’usual Suspects” encountered in hemovigilance, including patients presenting with atypical signs/symptoms/features, “combination reactions”, reactions with delayed onsets, the “Other” and “Not Easily Classifiable” reaction categories. By their nature recognition of such UTRs may point to atypical clinical presentations, or offer insights into potentially even new heretofore unrecognized types of reactions thus helping to inform hemovigilance surveillance activities and further our understandings of transfusion associated adverse events in general.
The ideal audience for this session includes clinical and laboratory staff involved with the recognition and management of patients experiencing suspected transfusion reactions. Cases presented will be derived from local, regional and national hemovigilance networks. Where pertinent, a global perspective will be integrated into the case discussions.
Audience members will be polled about their experiences with unusual transfusion reactions. Knowledge checks will be used at the start and end of the sessions to highlight important take-way messages. Participants will also have an opportunity to share and discuss their most intriguing UTRs and to explore unanswered questions regarding them.
Associate unexpected signs and symptoms with a transfusion.
Recognize unusual transfusion reactions.
Classify unusual transfusion reactions according to the CDC Hemovigilance Surveillance Protocol
List and describe the types of unusual transfusion reactions.
Discuss the definition, pathophysiology, signs, symptoms, therapies, prevention, clinical work-up and laboratory investigation (if applicable) of unusual transfusion reactions.
Please note: Yanyun Wu, MD, PhD did not consent to be recorded; therefore, the on-demand presentation and handout have been modified accordingly.
Medical Director of System Transfuion Medicine,
Baystate Health / Baystate Medical Center