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ST1-4: Paternity Testing & Human Identification: How methods developed for blood banking led to advances in criminal investigations and vice versa


Oct 19, 2019 8:00am ‐ Oct 19, 2019 9:30am

Description

Clinical and forensic molecular biology laboratories utilize some of the same chemistry, software and instrumentation that produce test data to determine human identity. Research and clinical laboratory testing have advanced the field of forensic casework and vice versa. In the first presentation, we will survey the field of clinical molecular testing over the past 25 years, highlighting technical innovations that have led to testing familiar to most of us, including: engraftment monitoring for bone marrow transplantation, chimerism testing for transfusion-associated GVHD analysis, and parentage testing. In the second presentation, we will examine forensic identity testing through case studies using advanced technologies, such as: next generation sequencing, bioinformatics, mixture deconvolution and probabilistic genotyping. Finally, we will explore future directions for clinical and forensic laboratories using advanced technologies.

Learning Objectives:

  • Discuss the similarities in molecular testing performed in clinical and forensic laboratories.
  • Summarize advances made possible by the knowledge gained from the sequencing of a million human genomes.
  • Describe software tools to consider in both clinical and forensic disciplines.

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