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ST4-31: Cases and Lessons Learned from Serological and Molecular Cases in Patients with Ethnic Diversity


Oct 19, 2019 1:30pm ‐ Oct 19, 2019 3:00pm

Description

In an increasing ethnically diverse world, hospital systems and blood centers are encountering more serological and molecular cases which require special care in their investigation. This session will look at the patient's ethnicity and the investigation which was required to drive the serological and molecular testing. The initial investigation, background on the patient, serological and molecular investigation along with the American Rare Donor Program's role in finding potential donors will be discussed. 

Molecular advances in recent years have lead to the discovery of more than 300 antigens and 36 blood group systems. As a result of this improved science, more antibodies have been identified which are often linked to certain ethnicities. We live in a global world which allows for increased movement with the ease of travel to all corners of the globe. This has translated to immunohematology reference laboratories receiving an increase in cases from ethnically diverse patients.

In lacking these high prevalence antigens, many ethnic patients have formed antibodies requiring increasingly complex immunohematology workups. These cases often require more work and time spent in patient history gathering, serological testing and molecular testing with increasingly improved and specific assays. These patients have required immensely more difficult sourcing of liquid and frozen red blood cell products, often with help from the American Rare Donor Program(ARDP).

Learning Objectives:

  • Assess ethnicity in solving complex immunohematology cases.
  • Investigate serological and molecular methods in solving complex cases.
  • Develop a plan for laboratories to aid them in the antigen and antibody identification and the search for compatible blood products for ethnically diverse patients.

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