Heparin induced thrombocytopenia (HIT), a life-threatening, acquired pro-thrombotic condition, remains a diagnostic and therapeutic challenge. From a clinico-pathological perspective, newer approaches such as the HIT Expert Probability (HEP) score for ICU patients, and the PF4-dependent P-selectin expression assay appear to be improvements over previous diagnostic tools. In addition, newer approaches (encompassing the role of direct oral anticoagulants, IVIg, and therapeutic apheresis to the treatment of HIT will be discussed. The medical literature supporting these newer diagnostic and treatment approaches will be reviewed. In addition, this session will challenge participants to use these diagnostic and therapeutic approaches in a variety of clinical scenarios.
Compare functional and antigenic assays as well as newer functional assays used in the diagnosis of HIT.
Construct algorithms that utilize clinical scoring and laboratory testing for the diagnosis of HIT.
Compare and contrast the risks and benefits of the use of direct oral anticoagulant, plasma exchange and IVIG in the treatment of HIT.
Hospital of the University of Pennsylvania