Transfusion transmitted parasitic infections with malaria and Babesia can pose considerable life-threatening complications, especially in immunocompromised individuals. A major cause of complications arise from the incompletely understood knowledge of hyperhemolysis where uninfected red cells are also destroyed during infections, worsening the anemia and disease course. In this session, we will first give an overview of the incidence of these TT parasitic infections by geographical distribution. By comparing what is known of the parasites erythrocytic life-cycles, and preference for specific subsets of host red cells, we will discuss parasite entry and egress mechanism to highlight similarities and differences between malaria and babesia which may impact disease pathogenesis and hemolytic complications, and describe recent developments in our understanding of potential mechanisms that may contribute to bystander hemolysis, focusing on parasite-specific molecules as well as heme driven pathways of immune activation.
Discuss the prevalence and geographical distribution of transfusion of transmitted parasitic infections.
Discuss recent developments in understanding of the life-cycle and host cell preference of malaria and babesia parasites.
Describe advances in elucidating potential mechanisms of bystander hemolysis in malaria and babesia infections.
Please note:Louis Katz, MD and Cheryl Lobo, PhD did not consent to be recorded; therefore, the on-demand presentation and handout have been modified accordingly.
Center for Biologics Evaluation and Research, Food and Drug Administration