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On-Demand eCasts

21EL-606 On-Demand eCast: Immunohematology Boot Camp: Case Studies Involving MNS Genotyping

Expiration Date: Feb 10, 2023

Credits: None available.


Please note: AABB reserves the right to make updates to this program.

Live Program Date: Wednesday, February 10, 2021
Program Number: 21EL-606

Educational Track: Technical/Clinical
Topics: Antibody Identification, Blood Groups, Immunohematology, Patient Transfusion, Special Patients and Situations, Transfusion Safety
Intended Audience: Facilities that perform molecular testing, Hospital Blood Banks, Hospitals, Immunohematology Reference Labs (IRL’s), Laboratory Staff, Managers/Supervisors, Physicians, Scientists, Students (MD, MT, SBB), Technologists
Teaching Level: Intermediate

(titles and affiliations at the time of the live program)
Director/Moderator: Thandar Aye, MLS(ASCP)SBB, Lead Reference Laboratory Technologist, BloodworksNW, Seattle, WA
Speakers: Sunitha Vege, MS, Technical Director, Genomics Laboratory, New York Blood Center, Long Island City, NY; Christine Lomas-Francis, MSc, FIBMS, Technical Director, Immunohematology Laboratory, New York Blood Center, Long Island City, NY

Learning Objectives

After participating in this educational activity, participants should be able to:

  • Discuss the molecular bases for MNS antigen expression and glycophorin variants.
  • Recognize when to use molecular methods to solve serology problems.
  • Explain current testing strategies when altered GYPA and/or GYPB genes are suspected.

Program Description

The highly polymorphic MNS blood group system currently consists of 49 antigens that are carried on glycophorin A (GPA), glycophorin B (GPB) or on hybrids of these glycophorins. The glycophorins are encoded by the homologous genes GYP*A and GYP*B and another homologous gene, GYP*E, participates in gene rearrangements. Variant glycophorins may be detected by altered expression of M, N, S or s antigens or, if they lack a high prevalence antigen may be revealed by unusual antibody specificities. Antibody investigation or resolution of antigen typing discrepancies involving MNS antigens can be challenging without the combined application of serological and molecular techniques. In this program, problem solving approaches using a combination of serology and different molecular methods will be discussed and their application illustrated by case studies.

How to Claim Continuing Education Credit

  • Single Viewers: if you registered as a single viewer, complete the evaluation found on the "CE Information" tab after watching the video. By submitting the evaluation, you are attesting to watching the presentation in its entirety.
  • Group Viewers: This is applicable for groups/facilities that purchased Group Viewing access for this program (registration will be verified prior to processing a group viewing attendance log). Group Viewing Coordinators should submit the attendance log to within 72 hours of the completion/viewing date. Once AABB receives an attendance log, each participant on the attendance log will be granted access as a single viewer to this program and will be required to complete the evaluation in order to claim continuing education credit. Each participant will be required to have an AABB account in order to access this program/platform. If a participant does not have an account, he/she can create one using the same email address provided on the attendance log.

Director & Moderator(s):

  • Thandar Aye, MLS(ASCP)SBB, Senior Reference Laboratory Technologist, BloodworksNW



  • 1.00 - General Continuing Education (GEN)
  • 1.00 - Florida Lab Personnel (FLP)
  • 1.00 - California Lab Personnel (CLP)

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