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On-Demand eCasts

21EL-670 On-Demand eCast: Role of HLA in Hematopoietic Stem Cell Transplantation and Other Donor Selection Criterion

Expiration Date: Aug 31, 2024

Credits: None available.


Live Program Date: Wednesday, September 1, 2021
Program Number: 21EL-670

Educational Track: Scientific
Topics: Cellular Therapy, Chimerism, Complications, Cord Blood, Donation, Immunosuppression, Patient Transfusion, Relapse, Therapeutic Apheresis, Transfusion Safety
Intended Audience: Directors, Donor Recruitment Staff, Facilities that perform molecular testing, Laboratory Staff, Managers/Supervisors, Medical Directors, Physicians, Research Scientists, Residents/Fellows, Scientists, Students (MD, MT, SBB), Technologists
Teaching Level: Advanced, Intermediate

(titles and affiliations at the time of the live program)
Director: Indira Guleria, PhD Diplomate (ABHI), Associate Director, HLA Tissue Typing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA
Moderator: Thomas Spitzer, MD, Director Emeritus, Bone Marrow Transplant Program, Walter Bauer Firm Chief, Massachusetts General Hospital, Professor of Medicine, Harvard Medical School, Boston, MA
Speakers: Indira Guleria, PhD Diplomate (ABHI), Associate Director, HLA Tissue Typing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA; Mahasweta Gooptu, MD, Attending Physician, Adult Stem-Cell Transplantation, Dana-Farber Cancer Institute; Assistant Professor, Harvard Medical School, Boston, MA

Program Description
Hematopoietic stem cells are self renewing, multipotent cells with malignancies of these cells being fatal and their replacement with normal stem cells is often required to cure disease. Human Leukocyte antigens (HLA) antigens are histocompatibility antigens and disparity in HLA antigens between stem cell transplant donor and recipients is one of the most important factors influencing transplant outcomes such as relapse, graft failure and graft vs host disease. Donor selection criteria including HLA matching, sensitization to HLA in selecting mismatch and role of non-HLA components in selection process for stem cell transplants will be discussed. Concept of “permissive mismatch” will be covered as well. This program will review the available approaches, and the benefits and limitations of each of the post-transplant monitoring methodologies the HLA labs utilize to measure donor engraftment.

Learning Objectives
After participating in this educational activity, participants should be able to:

  • Describe the diseases treated with transplantation of hematopoietic progenitor cells with view to discuss the pros and cons of different sources of stem cells.
  • Discuss donor selection criteria and the donor search process and impact of donor and recipient HLA disparity on graft outcomes.
  • Describe the assays for HLA typing of patient and potential donors, screening for antibodies to HLA and post-transplant chimerism monitoring to determine engraftment of donor cells.

How to Claim Continuing Education Credit

  • Single Viewers: if you registered as a single viewer, complete the evaluation found on the "CE Information" tab after watching the video. By submitting the evaluation, you are attesting to watching the presentation in its entirety.
  • Group Viewers: This is applicable for groups/facilities that purchased Group Viewing access for this program (registration will be verified prior to processing a group viewing attendance log). Group Viewing Coordinators should submit the attendance log to within 72 hours of the completion/viewing date. Once AABB receives an attendance log, each participant on the attendance log will be granted access as a single viewer to this program and will be required to complete the evaluation in order to claim continuing education credit. Each participant will be required to have an AABB account in order to access this program/platform. If a participant does not have an account, he/she can create one using the same email address provided on the attendance log.

Director & Speaker(s):

  • Dr. Indira Guleria, Ph.D. Diplomate (ABHI), Department of Medicine, Renal Division, Brigham and Women's Hospital




  • 1.50 - General Continuing Education (GEN)
  • 1.50 - Florida Lab Personnel (FLP)
  • 1.50 - California Lab Personnel (CLP)

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