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Credits: None available.
Live Program Date: Wednesday, September 1, 2021
Program Number: 21EL-670
Educational Track: Scientific
Topics: Cellular Therapy, Chimerism, Complications, Cord Blood, Donation, Immunosuppression, Patient Transfusion, Relapse, Therapeutic Apheresis, Transfusion Safety
Intended Audience: Directors, Donor Recruitment Staff, Facilities that perform molecular testing, Laboratory Staff, Managers/Supervisors, Medical Directors, Physicians, Research Scientists, Residents/Fellows, Scientists, Students (MD, MT, SBB), Technologists
Teaching Level: Advanced, Intermediate
(titles and affiliations at the time of the live program)
Director: Indira Guleria, PhD Diplomate (ABHI), Associate Director, HLA Tissue Typing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA
Moderator: Thomas Spitzer, MD, Director Emeritus, Bone Marrow Transplant Program, Walter Bauer Firm Chief, Massachusetts General Hospital, Professor of Medicine, Harvard Medical School, Boston, MA
Speakers: Indira Guleria, PhD Diplomate (ABHI), Associate Director, HLA Tissue Typing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA; Mahasweta Gooptu, MD, Attending Physician, Adult Stem-Cell Transplantation, Dana-Farber Cancer Institute; Assistant Professor, Harvard Medical School, Boston, MA
Hematopoietic stem cells are self renewing, multipotent cells with malignancies of these cells being fatal and their replacement with normal stem cells is often required to cure disease. Human Leukocyte antigens (HLA) antigens are histocompatibility antigens and disparity in HLA antigens between stem cell transplant donor and recipients is one of the most important factors influencing transplant outcomes such as relapse, graft failure and graft vs host disease. Donor selection criteria including HLA matching, sensitization to HLA in selecting mismatch and role of non-HLA components in selection process for stem cell transplants will be discussed. Concept of “permissive mismatch” will be covered as well. This program will review the available approaches, and the benefits and limitations of each of the post-transplant monitoring methodologies the HLA labs utilize to measure donor engraftment.
After participating in this educational activity, participants should be able to:
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