Decreasing platelet donors and increasing usage due to an aging population with losses due to new sampling requirements for bacteria detection may lead to shortages. Recent changes to deferral policies (e.g.,12 to 3 months) speak to the need to retain more donors. Pathogen reduction technologies (PRT) could allow further deferral relaxation (e.g., deferrals for men who have had sex with other men or travel to malaria endemic countries) and replacement of screening to increase platelet and plasma availability. To maintain blood supply continuity amid emergence of transfusion-transmitted diseases and in times of disaster, preparedness plans including rapid scalability of PRT for the platelet and plasma supply to allow for temporary deferral relaxation and increased production would be required. The session concludes considering PRT as part of business continuity plans of blood centers and hospitals to avoid critical shortages.