In the US, most facilities do not participate in organized hemovigilance systems due to the large resource commitment required to conduct robust transfusion surveillance with manual data capture. This session will present two distinct systems designed to leverage the power of electronic medical records for managing hemovigilance at the hospital level. In one system, real-time monitoring of all transfusion events in a large medical oncology center is deployed as a transfusion safety backstop. In the other system data collected by both automated and “manual prospecting” approaches from the patient’s electronic health record are used for clinical alerting, bedside hemotherapy monitoring, suspected transfusion reaction investigation/reporting, and analyses for quality improvement initiatives to enhance patient safety during hemotherapy interventions. Both facilities will share their experiences and transfusion safety gains related to adopting these methods.