Red cell antibody identification in 95% of cases referred to Immunohematology Reference Lab is straight forward, being single, multiple, or autoantibodies. But for the remaining 5%, antibody identification is challenging, requiring the most experienced and educated minds, and the best resources for multiple serologic and molecular techniques. In these cases, resolution also means knowledge of most appropriate blood for transfusion. Complex immunohematology cases may involve unknown high prevalence antibodies, complex transfusion and transplant histories and the presence of RHD and RHCE antigen variants. We will utilize chat boxes by pausing during critical parts to query the audience on what the next steps may be in the case. This will be presented by recognized experts in this discipline. This event will actively engage the participants to test their skills and knowledge and will result in skill development in resolving highly complex antibody identification cases.