COVID-19 convalescent plasma (CCP) from individuals recently recovered from SARS-CoV-2 infection is an important therapeutic option for individuals at risk for severe complications from COVID-19. Ensuring donor safety is of paramount importance for collection of CCP. Common donor adverse events (DAEs) generally involve complications such as vasovagal reactions, local arm pain or hematomas, as well as reactions related to apheresis collections. Other unique aspects related to donor health in individuals recovered from COVID-19 must also be considered, including donors who have received COVID-19 Convalescent Plasma (CCP) or monoclonal antibody therapy, as well as SARS-CoV-2 vaccination post-recovery. The AABB Donor Hemovigilance Working Group will share the results from their multi-institutional study analyzing key safety metrics related to the collection of CCP. Join this session to learn about new insights on donor hemovigilance gleaned from recent efforts collecting CCP.
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Identify challenges encountered by blood centers with the collection of CCP donors related to the impact of unique eligibility requirements
List examples of common blood center protocols to improve donation safety during the COVID-19 pandemic
Recognize differences in risks factors for donor adverse events (DAEs) in CCP donors compared to conventional plasma donors identified in a large multicenter study
Define acceptance criteria for collection of COVID-19 Convalescent Plasma (CCP) and variations between organizations screening for suitable donors
Innovative Blood Resources, division of New York Blood Center
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AM21-56: COVID-19 Convalescent Plasma: Impact on Donation Safety and Eligibility Evaluation