This session will explore the collection and use of COVID-19 convalescent plasma (CCP). Dr. Sachais will describe his center’s experience as a blood collection center during COVID-19 and address and describe issues with implementing a CCP program. Dr. Simon will describe the experience of plasma collection centers in the plasma consortium during COVID-19 and the implementation of a CCP collection program. Speakers will address donor recruitment and collection issues including trends across the country in CCP collection. The selection criteria for CCP donors will be discussed. Speakers will describe methods used to test donor antibody levels and describe trends in antibody decline over time. Effect of ethnicity, gender and other donor characteristics on COVID-19 antibody levels and decline will be presented. Differences in total and neutralizing antibodies will be discussed. The use and efficacy of CCP to treat COVID-19 in different patient populations will be summarized.