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AM21-60: Apheresing Heartbreak: Etiology and Treatment of Antibody-Mediated Cardiac Allograft Rejection


Oct 19, 2021 9:00pm ‐ Oct 19, 2021 10:00pm



Credits: None available.

Description


Anti-Human Leukocyte Antigen (HLA) donor specific antibodies (DSA) and anti-Angiotensin II Receptor Type 1 (AT1R) antibodies threaten short and long-term cardiac allograft survival. In this symposium we review the role of anti-HLA DSA and anti-AT1R antibodies in acute and chronic cardiac transplant antibody-mediated (AMR) rejection. We outline antibody-mediated allograft injury mechanisms, both complement dependent and independent, and describe HLA, other DSA and AT1R antibody detection, attributes and clinical correlates. We discuss the role of apheresis in AMR informed by one of the largest cardiac rejection cohorts in the United States. We hope to harness data from this evolving field to better manage antibody-mediated allograft rejection and to ultimately improve long-term allograft outcomes.

Speaker(s):

  • Dr. Jensyn Cone Sullivan, MD, Tufts Medical Center
  • Elaine Reed, PhD, UCLA Immunogenetics Center, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles

Moderator(s):

Credits

Credits: None available.

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