Healthcare landscape challenges such as increasing medical legal concerns, sicker patients and higher patient expectations have required blood centers to redefine their current business models. An increasing number are looking to adjacent lines of business for possible synergies and new revenue streams. A physician-run clinic specializing in transfusion medicine services may be the right model for some centers. This session will explore the business and medical cases for developing an outpatient physician run transfusion medicine clinic within the confines of a blood center. The requirements for analyzing, developing, implementing and sustaining such a model will be discussed. The scope of services currently offered (e.g. therapeutic phlebotomy and outpatient therapeutic apheresis) and potential future services (e.g., preop anemia evaluation and treatment, iron deficiency evaluation and treatment and outpatient transfusion) will be evaluated on how to best meet changing needs.