Due to lockdown and social distancing measures during COVID-19, blood donations dropped significantly at the start of the pandemic. Blood centers (BC) had to continuously adapt to reduction in donations, loss of staff due to COVID-19 exposure and quarantine, and uncertain patterns of demand for blood components. Elective surgeries were temporarily cancelled. Hospital transfusion services had to interact with the BC to continuously maintain the blood supply to meet demand for ongoing critical need. Patient blood management (PBM) is an evidence-based, multidisciplinary approach to optimize the care of patients who might need a transfusion. Following its principles (anemia management, minimization of surgical bleeding and iatrogenic anemia, and guideline-oriented transfusions) was critical during COVID-19 pandemic to ensure adequate blood supply. This session ends with a summary of key lessons learned by blood centers and hospitals during the COVID-19 pandemic.