AM21-68: In Vitro and In Vivo Evidence for the Use of Cold Stored Platelets

Description

Standard platelet units are stored at room temperature (20-24°C) for up to 5 to 7 days. This short expiration date limits platelet supply, particularly in rural areas. In addition, platelet function declines and bacterial growth may occur in this storage condition. Alternative strategies to preserve platelets are needed to ensure adequate platelet supply for all bleeding patients. Platelets are currently FDA approved to store cold (1-6°C) for up to 3 days. Laboratory data suggests that cold storage may preserve platelet function longer, up to more than 20 days. Clinical data suggests that cold stored platelets may be effective in controlling bleeding. This session will review the in vitro and in vivo data available on the use of cold stored platelets.

---

To view Spanish or English subtitles, click the "CC" box in the video player.
Para ver subtítulos en español o inglés, haga clic en el cuadro "CC" en el reproductor de video.

---

Learning Objectives:

• Differentiate the impact of cold and room temperature storage on platelet function.
• Describe the data on clinical use of cold stored platelets.
• Review storage conditions for platelets.

Speaker(s):

• Dr. Moritz Stolla, MD, University of Washington School of Medicine
• Dr. Kimberly A. Thomas, PhD, Washington University in St. Louis, Pediatrics Critical Care Dept.

Moderator(s):

• Dr. Nicole D. Zantek, MD, PhD, Department of Laboratory Medicine and Pathology, University of Minnesota

Disclosures

• Nicole Zantek, MD, PhD : Spouse Stock Shareholder: ENDO International PLC; Spouse Employee: Boston Scientific
• Moritz Stolla, MD : Grant/Research Support: Terumo, Cerus
• Kimberly Thomas, PhD : Nothing to Disclose