Standard platelet units are stored at room temperature (20-24°C) for up to 5 to 7 days. This short expiration date limits platelet supply, particularly in rural areas. In addition, platelet function declines and bacterial growth may occur in this storage condition. Alternative strategies to preserve platelets are needed to ensure adequate platelet supply for all bleeding patients. Platelets are currently FDA approved to store cold (1-6°C) for up to 3 days. Laboratory data suggests that cold storage may preserve platelet function longer, up to more than 20 days. Clinical data suggests that cold stored platelets may be effective in controlling bleeding. This session will review the in vitro and in vivo data available on the use of cold stored platelets.