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2022 AABB Virtual Annual Meeting

AM22-ST04-L - AM22-ST04-L: How an Anti-c Antibody Prompted a 10-Year Journey of Life Saving Work Between a Transfusion Service and a Blood Center Reference Laboratory (Live)

Oct 1, 2022 8:30am ‐ Oct 1, 2022 9:30am

Credits: None available.


Blood Centers are excellent in the provision of antigen negative red blood cells. So much so, that the very limited availability of blood for patients with rare blood needs may not be fully recognized by the patient, family, or their physician. Understanding the impact of rare blood requirements and the interventions needed to sustain human lives are an important point to bring to light. A patient's story who is O negative(r'r') with anti-c and anti-Jka and the lifesaving work which was done to continue to get red cell products for him will be shared. The American Rare Donor Program's role in the sourcing of national and international red cell units for this patient will be discussed and will also include other patients who have required national and international searches for products will also be discussed. Difficult transfusion decisions will also be discussed: giving incompatible blood products, red blood cell survival (extrinsic vs. extrinsic cell destruction), Monocyte Monolayer Assay (MMA), and immunologic concerns for this patient's antibodies and concerns in crossing patients with other red blood cell antigen groups.

Learning Objectives:
  • Plan for the care of a patient with rare antigen needs.
  • Explain the complexity in making difficult serological, transfusion and ethical patient decisions.
  • Identify the testing and the steps needed to choose the best next step to sustain a patient's life.



  • Dr. Margaret A. Keller, PhD, Director, National Molecular Laboratory, American Red Cross Biomedical Services


  • Gavin Patch, SBB MBA-HCM : Nothing to Disclose
  • Margaret Keller, PhD : Nothing to Disclose
  • Joan Maurer, BS, SBB(ASCP) : Nothing to Disclose


Credits: None available.

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