Faculty (titles and affiliations at the time of the live program) Director/Moderator: Huy P. Pham, MD, MPH, Medical Director, National Marrow Donor Program (NMDP), Seattle, WA Speakers: Patricia A. Shi, MD, Medical Director, New York Blood Center, New York, NY Ross Fasano, MD, Associate Professor, Emory University, Atlanta, GA Monika Paroder, MD, PhD, Assistant Professor, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
Program Description Sickle cell disease is affected approximately 100,000 people in the United States. It is a major public health concern and the patients have a significant morbidity and mortality. At this time, transfusion of red blood cells (RBCs) is one of the main treatment strategies for this disease. However, transfusion is potentially associated with multiple complications, including transfusion-transmitted infections and alloimmunizations.
Given that there are few quality studies investigated the effect of simple vs. exchange transfusion in patients with sickle cell disease, this program will summarize the current data and expert opinion on the use of each treatment modality. Key considerations that physicians should be aware of when choosing between treatment options as well as challenges in pediatric patients will also be addressed. Lastly, novel therapies in the treatment of sickle cell disease, including cellular therapies, will be discussed.
Learning Objectives After participating in this educational activity, participants should be able to:
Discuss considerations for simple vs. exchange transfusions in patients with sickle cell disease.
Summarize key considerations in using different treatment options in pediatric patients.
Describe current novel therapies, including cellular therapies, as treatment modalities in sickle cell disease.
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