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AM21-14: Evolving Use of Rh Antigen Genotyping for Improved Red Cell Transfusion Matching

‐ Oct 17, 2021 6:00pm

Expiration Date: Dec 31, 2023

Credits: None available.

Alloimmunization to non-ABO antigens is one of the most common complications of blood transfusions. Blood group antigen profiling and prophylactic antigen matching have reduced but not eliminated alloimmunization. DNA-based genotyping methods enable accurate prediction of most blood group antigen phenotypes. Compared to traditional serologic typing, genotyping is particularly useful for patients with recent transfusion or to identify low frequency antigens for which serologic reagents are not available. Genotyping can also identify variant RH alleles that are common in patients with sickle cell disease, allowing more precise matching between patients and blood donors. In this session, we will review the challenges for blood group antigen genotyping focusing on Rh antigens, and discuss strategies to incorporate genotyping results to improve red cell matching and prevent alloimmunization.

To view Spanish or English subtitles, click the "CC" box in the video player.
Para ver subtítulos en español o inglés, haga clic en el cuadro "CC" en el reproductor de video.

Learning Objectives:

  • Discuss the advantages of blood group antigen genotyping
  • Discuss approaches for RH genotyping, including whole genome sequencing.
  • Discuss strategies to apply blood group antigen genotyping to improve red cell matching.




  • Stella Chou, MD:
    Consultant: PlateletBio
  • Connie Westhoff, SBB, PhD:
    Nothing to Disclose
  • Yan Zheng, MD/PhD:
    Nothing to Disclose

All relevant financial relationships have been mitigated. By completing the evaluation, you are attesting to watching the presentation in its entirety. A certificate will be immediately provided after submission.

Credits Available

AM21-14: Evolving Use of Rh Antigen Genotyping for Improved Red Cell Transfusion Matching Evaluation