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AM21-60: Apheresing Heartbreak: Etiology and Treatment of Antibody-Mediated Cardiac Allograft Rejection


‐ Oct 19, 2021 9:00pm

Expiration Date: Dec 31, 2023


Credits: None available.

Anti-Human Leukocyte Antigen (HLA) donor specific antibodies (DSA) and anti-Angiotensin II Receptor Type 1 (AT1R) antibodies threaten short and long-term cardiac allograft survival. In this symposium we review the role of anti-HLA DSA and anti-AT1R antibodies in acute and chronic cardiac transplant antibody-mediated (AMR) rejection. We outline antibody-mediated allograft injury mechanisms, both complement dependent and independent, and describe HLA, other DSA and AT1R antibody detection, attributes and clinical correlates. We discuss the role of apheresis in AMR informed by one of the largest cardiac rejection cohorts in the United States. We hope to harness data from this evolving field to better manage antibody-mediated allograft rejection and to ultimately improve long-term allograft outcomes.


To view Spanish or English subtitles, click the "CC" box in the video player.
Para ver subtítulos en español o inglés, haga clic en el cuadro "CC" en el reproductor de video.



Learning Objectives:

  • Summarize HLA- and AT1R-antibody detection and antibody-mediated allograft injury diagnosis
  • Examine the role for apheresis in antibody-mediated allograft rejection by examining a large cohort of cardiac allograft patients
  • Describe the mechanisms of antibody-mediated cardiac allograft injury

Speaker(s):

Moderator(s):

Disclosures

  • Raymond Comenzo, MD:
    Nothing to Disclose
  • Jensyn Cone Sullivan, MD:
    Nothing to Disclose
  • Elaine Reed, PhD:
    Nothing to Disclose

All relevant financial relationships have been mitigated. By completing the evaluation, you are attesting to watching the presentation in its entirety. A certificate will be immediately provided after submission.

Credits Available


AM21-60: Apheresing Heartbreak: Etiology and Treatment of Antibody-Mediated Cardiac Allograft Rejection Evaluation