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Nearly all red cell antibody identification cases referred to IRLs are straightforward, being single, multiple, or autoantibodies. But in a small percentage, antibody identification is challenging, requiring the most experienced and educated minds and the best resources for various serologic and molecular techniques. This session will review a few specific case studies to demonstrate the resolution challenging antibody investigations and provide recommendations for the most appropriate blood for transfusion. Complex immunohematology cases may involve unknown high-prevalence antibodies, complex transfusion and transplant histories, and the presence of RHD and RHCE antigen variants.
Learning Objectives:
Illustrate the process for test selection to effectively solve complex immunohematology cases
Design detailed differentials for the choices of test approaches and resources
Integrate multiple test results into a comprehensive antibody interpretation and transfusion plan
Moderator(s):
Paul
Mansfield,
MLS(ASCP)SBB,
Director, IRL,
American Red Cross
Speaker(s):
Janis
Hamilton,
MS, MLS(ASCP)SBB,
Manager, IRL,
American Red Cross
Thierry
Peyrard,
PharmD, PhD, EurSpLM,
Head of Department,
Etablissement Français du Sang Île-de-France, CNRGS; Université Paris Cité and Université des Antilles, INSERM, BIGR
Disclosures
Janis Hamilton, MS, MLS(ASCP)SBB:
No financial relationships to disclose
Paul Mansfield, MLS(ASCP)SBB:
No financial relationships to disclose
Thierry Peyrard, PharmD, PhD, EurSpLM:
No financial relationships to disclose
All relevant financial relationships have been mitigated.