Nearly all red cell antibody identification cases referred to IRLs are straightforward, being single, multiple, or autoantibodies. But in a small percentage, antibody identification is challenging, requiring the most experienced and educated minds and the best resources for various serologic and molecular techniques. This session will review a few specific case studies to demonstrate the resolution challenging antibody investigations and provide recommendations for the most appropriate blood for transfusion. Complex immunohematology cases may involve unknown high-prevalence antibodies, complex transfusion and transplant histories, and the presence of RHD and RHCE antigen variants.
Illustrate the process for test selection to effectively solve complex immunohematology cases
Design detailed differentials for the choices of test approaches and resources
Integrate multiple test results into a comprehensive antibody interpretation and transfusion plan