AM23-SN-11-O: Challenging Antibody Investigations in the Immunohematology Reference Lab (Enduring)

Nearly all red cell antibody identification cases referred to IRLs are straightforward, being single, multiple, or autoantibodies. But in a small percentage, antibody identification is challenging, requiring the most experienced and educated minds and the best resources for various serologic and molecular techniques. This session will review a few specific case studies to demonstrate the resolution challenging antibody investigations and provide recommendations for the most appropriate blood for transfusion. Complex immunohematology cases may involve unknown high-prevalence antibodies, complex transfusion and transplant histories, and the presence of RHD and RHCE antigen variants.