AM24-MN-09-O: Management of Hematotoxicity from Immune Effector Cell Therapy and Sickle Cell Disease Gene Therapy (Enduring)

CABP CE Eligible

Immune effector cell (IEC) therapies for hematologic disease and gene therapies for sickle cell disease (SCD) are rapidly proliferating. As such, transfusion medicine specialists need to be aware of the hematologic toxicities associated with both types of therapies. With IEC therapies, most are aware of cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome. However, hematologic toxicities make up the highest cumulative incidence of all adverse events following CAR-T cell therapy and encompass early and late cytopenias, coagulopathies, bleeding and clotting events, hemophagocytic lymphohistiocytosis-like syndrome, and tumor lysis syndrome. The risk of acute myeloid leukemia post-transplant and the contribution of clonal hematopoiesis must be considered with gene therapy for SCD. Alpha-thalassemia trait may contribute to dyserythropoiesis post-gene therapy for SCD. Dr. Doris Hansen will review the pathophysiology and management of the hematologic toxicities associated with IEC therapy. Dr. Michael DeBaun will discuss the pathophysiology of increased risk of AML and dyserythropoiesis post-gene therapy and potential strategies to reduce this risk.