CABP CE Eligible

A hallmark of the ageing hematopoietic system is a skewing of lineage output from balanced to myeloid-biased, which is hypothesized to result in compromised adaptive immunity and predisposition toward myeloid malignancies in aging individuals. More recently, changes in the composition of a heterogeneous HSC population with age (the population shift model) is being increasingly recognized to account for lineage output changes and the observed hematopoietic ageing phenotype may result from an expansion of myeloid-biased HSCs with exhaustion of lymphoid-biased and balanced HSCs. Importantly, research efforts continue investigate the molecular mechanisms associated with aging HSCs. In this session, we will explore the clinical impact of aging in BMT and how HSC function changes with the aging process. We will highlight recent discoveries that define the ageing HSC compartment and molecular mechanisms underlying these processes which potentially can be targeted to rejuvenate aged HSC function.

Katherine King MD, PhD

Baylor College of Medicine

Appearances