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AM24-MN-38-O

AM24-MN-38-O: Turning Over Every Rock: Exploring Advanced Techniques in Platelet and Red Blood Cell Autoantibody Testing (Enduring)

Date
October 23, 2024
Credits
1 General Continuing Education (GEN) | 1 Florida Lab Personnel (FLP) | 1 California Nurse (CN) | 1 California Lab Personnel (CLP) | 1 Physician (PHY)
$30
Standard Price
Members save $5
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Thumbnail for 2024 Annual Meeting On-Demand: FULL ACCESS
By far the best value to watch all the on-demand educational sessions from the 2024 AABB Annual Meeting and earn continuing education credit…

Autoantibodies to platelets and red blood cells can be clinically pronounced but serologically difficult to detect. Autoimmune thrombocytopenia can require multiple testing modalities to identify an offending autoantibody, and up to 10% of autoimmune hemolytic anemias are negative by standard direct antiglobulin testing (DAT) methods. Although both are hematopoietic-derived cells, the approaches and technologies used in identifying antibody-coated cells differ. For blood bankers and clinicians, understanding the key features of autoantibodies despite negative testing with standard methods will prompt the appropriate esoteric testing required for a diagnosis. In this program, the faculty will dive into the complexities of platelet serology and genotyping as well as red blood cell extended DAT methodologies for autoantibodies. A discussion of platelet autoantibodies to glycoproteins IIb/IIIa, Ib/IX, and Ia/IIa and red blood cell autoantibodies that are low affinity IgG, warm reacting IgM, and IgA will highlight the less often observed causes of autoimmune destruction of platelets and red blood cells.

Learning Objectives

  • Describe the serologic and molecular strategies to classify autoantibodies in autoimmune thrombocytopenia.
  • Describe the testing modalities to identify low affinity IgG, warm reacting IgM, and IgA red blood cell autoantibodies.
  • Recognize the serologic patterns of platelet and rare red blood cell autoantibodies.
  • Compare and contrast the methods to look for autoantibodies in platelets and red blood cells.
  • Understand the clinical features of autoantibodies to platelets and red blood cells.

Moderator

Speaker Image for Waseem Anani
University of Utah, ARUP Laboratories

Speakers

Speaker Image for Angela Treml
Medical College of Wisconsin, Medical Science institute Versiti
Speaker Image for Marisela Marchan
Marisela G. Marchan, MSTM, MLS(ASCP)SBBcm
Manager, Platelet, Neutrophil Immunology Laboratory, Versiti

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