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By far the best value to watch all the on-demand educational sessions from the 2024 AABB Annual Meeting and earn continuing education credit…
Autoantibodies to platelets and red blood cells can be clinically pronounced but serologically difficult to detect. Autoimmune thrombocytopenia can require multiple testing modalities to identify an offending autoantibody, and up to 10% of autoimmune hemolytic anemias are negative by standard direct antiglobulin testing (DAT) methods. Although both are hematopoietic-derived cells, the approaches and technologies used in identifying antibody-coated cells differ. For blood bankers and clinicians, understanding the key features of autoantibodies despite negative testing with standard methods will prompt the appropriate esoteric testing required for a diagnosis. In this program, the faculty will dive into the complexities of platelet serology and genotyping as well as red blood cell extended DAT methodologies for autoantibodies. A discussion of platelet autoantibodies to glycoproteins IIb/IIIa, Ib/IX, and Ia/IIa and red blood cell autoantibodies that are low affinity IgG, warm reacting IgM, and IgA will highlight the less often observed causes of autoimmune destruction of platelets and red blood cells.
Learning Objectives
Describe the serologic and molecular strategies to classify autoantibodies in autoimmune thrombocytopenia.
Describe the testing modalities to identify low affinity IgG, warm reacting IgM, and IgA red blood cell autoantibodies.
Recognize the serologic patterns of platelet and rare red blood cell autoantibodies.
Compare and contrast the methods to look for autoantibodies in platelets and red blood cells.
Understand the clinical features of autoantibodies to platelets and red blood cells.
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AM24-MN-38-O: Turning Over Every Rock: Exploring Advanced Techniques in Platelet and Red Blood Cell Autoantibody Testing (Enduring) Evaluation
This is a first in a proposed series where we will look at antibodies to red cell antigens that are more prevalent in different parts of the world. Our journey starts in the Shire (USA) as we encounter antibodies relevant to the area we work in…
What do you do when you discover an unexpected antigen typing? Do you investigate history, rule out sample switch, opt for a different serologic technique, or refer for DNA testing? What about when you encounter an antibody of unidentified specificity? Which test do you perform next, and once the a…