AM24-MN-34-O: Mechanisms and Technologies Towards Expanding Hematopoietic Stem Cells for Transplantation (Enduring)
CABP CE Eligible
Hematopoietic stem cells (HSCs) are the apex hematopoietic cell with the potential to produce robust and lifelong production of all blood cells. Thus, understanding the details of HSC molecular biology is critical to our understanding of human health and longevity. Mechanistic insights into HSC biology could be leveraged to further improve the strategies available to maintain and expand functional HSCs in vitro. Overcoming these hurdles is critical to effectively use HSCs for off-the-shelf allogeneic HSC transplantation or gene-editing of autologous HSCs for treatments of hematological disease and malignancies. In this session, we will discuss the most recent applications of HSC expansion technology currently in clinical use. We will also explore the latest mechanistic breakthroughs towards producing abundant HSCs in vitro for use in transfusion applications.
Learning Objectives
- Uncover latest mechanistic underpinnings of hematopoietic stem cell (HSC) cycling and maintenance of stem cell self-renewal in vitro.
- Define the molecular mechanisms and that contribute to exhaustion of HSCs under tissue culture conditions.
- Describe the latest advances in technologies and methods to expand functional HSCs and de novo generation of HSCs in vitro.
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