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AM24-ST-22-O

AM24-ST-22-O: Cryopreserved Platelets: From Bench to Bedside (Enduring)

Date
October 23, 2024
Credits
1 General Continuing Education (GEN) | 1 Florida Lab Personnel (FLP) | 1 California Nurse (CN) | 1 California Lab Personnel (CLP) | 1 Physician (PHY)
$30
Standard Price
Members save $5
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This session will explore the characteristics of cryopreserved platelets from laboratory studies, followed by the first presentation of the results from the CLIP-II clinical trial. The CLIP-II trial is a phase III multicentre blinded randomised controlled clinical non-inferiority trial of cryopreserved platelets versus conventional liquid-stored platelets for the management of surgical bleeding. In the first presentation, laboratory investigations of the functional qualities of cryopreserved platelets and their haemostatic capacity will be described. Production methods of cryopreserved platelets, management of an inventory of cryopreserved platelets and health economic considerations will also be discussed. The session will then move to presentation of the outcomes of the CLIP-II trial, with emphasis on how they may change transfusion practice, particularly for bleeding patients. Data from other trials will also be explored, which suggest cryopreserved platelets may be less effective than expected for indications such as correcting a low platelet count in non-bleeding patients. This will be the first time that the results of the CLIP-II trial are presented.

Learning Objectives

  • After attending this session, the audience will be able to describe the effects of cryopreservation on platelet morphology and phenotype
  • After attending this session, the audience will be able to compare the effects of cryopreservation on the haemostatic function of platelets with the characteristics of room-temperature stored platelets.
  • After attending this session, the audience will be able to identify how cryopreserved platelets can be used to manage platelet inventory in austere environments.
  • After attending this session, the audience will be able to describe the effectiveness of cryopreserved platelets for the treatment of bleeding in surgery and other indications, based on evidence from the CLIP-II trial and other clinical trials.
  • After attending this session, the audience will be able to describe the health economic considerations associated with production and use of cryopreserved platelets.

Moderator & Speaker

Speaker Image for DENESE MARKS
Research Program Leader, Australian Red Cross Lifeblood

Speaker

Speaker Image for Michael Reade
Michael Reade, MBBS, MPH, Dphil, DMedSc
University of Queensland

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