Professor Simon Stanworth is a Consultant Haematologist at John Radcliffe Hospital (NHSBT and Oxford University Hospitals Foundation Trust) and Professor of Haematology and Transfusion Medicine at University of Oxford. His applied research is centered on clinical indications of blood transfusion components, or alternatives to blood, through systematic reviews and clinical studies/trials. He has over 20 years of clinical research experience since gaining my DPhil in 1995 from the University of Oxford. His research is driven by patient needs, identified by multiple Patient and Public Engagement panels and work for James Lind Priority Setting Partnerships. Highlights have included multiple international randomized trials including those published in New England Journal of Medicine. He has published over 500 peer-reviewed research articles, for an H-index over 70. Very recent international trials published in high impact journals include CRYOSTAT2 (Joint Chief Investigator, Davenport et al, JAMA 2023). He has an interest in translating research into practice, through research and contributions to many national and international guidelines. Audit and Feedback is the most common quality improvement tool yet cumulative meta-analysis of A&F trials indicates that effect sizes stabilized over 10 years ago, suggesting a lack of learning on how to improve effectiveness. Building on collaborations with partner national audit programs, he has evaluated and tested new methods to enhance A&F and explore how to routinely embed such work within UK national audits. During the COVID response he led research on describing the impact of COVID19 on the whole transfusion chain, from donor to recipient, including responses in the event of blood shortages; defining the impact of COVID19 on patients with acute myeloid leukemia; and testing the effect of strategies for anti-coagulation in critically ill patients with COVID19 (published New England Journal of Medicine). He has collaborated with Dr. Carson and Pagano international guidelines on red cell transfusion thresholds.